The Trump administration has secured commitments from two dozen leading tech companies to participate in its Genesis Mission, an ambitious initiative designed to harness artificial intelligence (AI) for scientific breakthroughs in energy, national security, and other critical research areas.
The roster of participating firms represents a who’s who of the industry, including OpenAI, Microsoft Corp., Alphabet Inc.’s Google, Amazon Web Services (AWS), and NVIDIA Corp. The companies have either signed memorandums of understanding with the federal government, established projects with the Department of Energy (DOE) or its national laboratories, or expressed formal interest in joining the effort, according to a White House statement released Wednesday.
President Donald Trump launched the Genesis Mission last month through an executive order, establishing a framework to improve coordination across federal research agencies and accelerate scientific discovery using advanced AI capabilities.
“Today’s announcement of 24 new research partnerships is only the beginning, as we deliver on President Trump’s mandate to bring the entire scientific community, including companies, universities, non-profits, and federal agencies, into the Genesis Mission,” said Michael Kratsios, assistant to the President and Director of the Office of Science and Technology Policy.
Beyond the tech giants, the participant list includes Accenture, AMD Inc., Anthropic, Cerebras Systems Inc., CoreWeave Inc., Dell Inc., Groq Inc., Hewlett Packard Enterprise Co., IBM Corp., Intel Corp., Oracle Corp., Palantir Technologies Inc., Project Prometheus, Radical AI, and xAI. Administration officials emphasized that this initial roster represents just the beginning of what they expect to become a much larger collaborative effort.
“We’re proud to power this transformation from day one — not with promises of what might be possible, but with infrastructure that turns ambitious vision into operational reality today,” David Appel, vice president of global government, national security and defense, at AWS, said in a statement.
The Genesis Mission aims to integrate cutting-edge AI into the scientific process, enabling researchers to automate experiment design, accelerate simulations, and generate predictive models. Dario Gil, DOE Under Secretary for Science and Genesis Mission Director, said the initiative would dramatically increase the productivity of American scientists and could lead to transformative advances in energy, manufacturing, drug discovery, and other fields.
The program will rely heavily on computing resources housed within the Energy Department’s national laboratories. Kratsios has indicated the initiative would leverage these facilities to access federal datasets and enable researchers to conduct a greater volume of AI-led experiments. Officials argue that access to large-scale computing power will compress discovery timelines by allowing more simulations and more efficient exploration of complex scientific problems.
However, the administration has acknowledged that expanding AI research requires energy-intensive data centers. Officials have sought to pair the Genesis Mission with efforts to identify new energy sources and strengthen the power grid to meet growing computational demands.
The Trump administration has simultaneously moved to curb state-level AI regulations, arguing that inconsistent local rules could burden companies and stifle innovation. Critics counter that state-based regulations remain necessary to address risks including biased algorithms, deepfakes, and user safety concerns, particularly given slow progress on federal rulemaking.
The Energy Department said it will continue accepting submissions under two open requests for information. The “Partnerships for Transformational Artificial Intelligence Models” RFI remains open until Jan. 14, 2026, while the “Transformational AI Capabilities for National Security” RFI closes Jan. 23, 2026.
